| Cat. No. |
Product Name |
Information |
| PC-22096 |
BMS191095
KATP opener
|
BMS191095 (BMS-191095) is a selective ATP-sensitive potassium channel (KATP) opener, exhibits antiischemic (cardioprotective) potency with EC25 of 1.4 uM. |
| PC-21845 |
Tamapin TFA
SK2 channel inhibitor
|
Tamapin TFA salt is a venom peptide from the Indian red scorpion (Mesobuthus tamulus), potent and selective inhibitor of small conductance calcium-activated potassium channel 2 (SK2, KCNN2) with IC50 of 24 pM. |
| PC-21738 |
PNU37883A
Kir6 inhibitor
|
PNU37883A (PNU37883 hydrochloride) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker with IC50 of 6 uM and 15 uM for Kir6.1/SUR2B and Kir6.2/SUR2B, respectively. |
| PC-21737 |
Pinacidil
Potassium channel activator
|
Pinacidil (P-1134) is a potent activator of potassium channel, hyperpolarises vascular smooth muscle by opening K+-channels, significantly improves the reperfusion function and cardiac compliance and has direct cardioprotective efficacy. |
| PC-21704 |
Guangxitoxin 1E
Kv2 channel inhibitor
|
Guangxitoxin 1E is a potent, specific inhibitor of Kv2.1 (KCNB1) and Kv2.2 with IC50 of 1-3 nM, has no significant effect on KV1.2, KV1.3, KV1.5, KV3.2 and BK potassium channels, also inactive against calcium and sodium channels CaV1.2, CaV2.2, NaV1.5, NaV1.7, NaV1.8. |
| PC-21483 |
NPBA-4
TWIK2 inhibitor
|
NPBA-4 is a potent selective TWIK2 channel inhibitor with IC50 of 8.41 uM. shows little to no effects on TWIK1 channel. |
| PC-21482 |
NPBA
TASK-3 activator
|
NPBA is a potent, selective pharmacological activator for K2P channel TASK-3 with EC50 of 6.7 uM (TASK-3 whole-cell currents), shows good selectivity between TASK channels. |
| PC-21229 |
VU0935685
KNa1.1 (Slack) inhibitor
|
VU0935685 is a potent, selective inhibitor of SLACK potassium channels with IC50 of 0.32 uM in in whole-cell, voltage-clamp electrophysiology (EP) assays, demonstrates selectivity versus hERG. |
| PC-20943 |
ML252
KCNQ2 inhibitor
|
ML252 is a potent and selective, brain penetrant inhibitor of KCNQ2 (Kv 7.2) with IC50 of 69 nM, EC50 of 170 nM. |
| PC-20753 |
BK channel modulator BC5
BK channel modulator
|
BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism. |
| PC-20698 |
PK-THPP
TASK-3 inhibitor
|
TASK-3 inhibitor 23 is a potent, selective inhibitor of TWIK-related acid-sensitive K+ (K2P9.1, TASK-3) ion channel with IC50 of 30 nM, 10-fold selectivity over TASK-1. |
| PC-20697 |
A1899
TASK-1 inhibitor
|
A1899 (A-1899) is a potent and highly selective blocker of the K(2P) channel TASK-1, selectively blocks human TASK-1 channels expressed in Xenopus oocytes with IC50 of 35.1 nM. |
