BA6b9

Chemical Structure : BA6b9

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货号: PC-22989Not For Human Use, Lab Use Only.

BA6b9 is a small molecule, allosteric SK4 channel blocker, reversibly inhibits the SK4 currents with IC50 of 8.6 uM, targets Ca2+-calmodulin (CaM)-PIP2-binding domain.

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生物&药学活性

BA6b9 is a small molecule, allosteric SK4 channel blocker, reversibly inhibits the SK4 currents with IC50 of 8.6 uM, targets Ca2+-calmodulin (CaM)-PIP2-binding domain.
BA6b9 inhibits SK4 channels by interacting with two specific residues, Arg191 and His192 in the linker S4-S5, not conserved in SK1–SK3 subunits.
cytosol-facing CaM–PIP2-binding domain (CPBD).
BA6b9 (10 uM) potently inhibits the SK4 currents by 66%.
BA6b9 significantly prolonged atrial and atrioventricular effective refractory periods on the electrophysiological properties of the isolated rat hearts.

物理化学性质&存储条件

分子量	233.31
分子式	C14H19NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Heptyl-2(3H)-benzoxazolone

参考文献

1. Burg S, et al. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2202926119.

BA6b9

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BA6b9

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