C28 | KCNQ1 activator | Probechem Biochemicals

Chemical Structure : C28

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C28 (IKs activator C28)

货号: PC-23263Not For Human Use, Lab Use Only.

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250 mg		Get quote

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生物&药学活性

C28 is a specific small molecule activator of cardiac potassium ion channel IKs (KCNQ1+KCNE1), causes change of V1/2 of G-V relations with EC50 of 7.6 uM, interacts with the KCNQ1 voltage-sensing domain (VSD), and shifts voltage dependence of VSD activation to more negative voltages.
C28 specifically shifted IKs VSD activation in ventricle to more negative voltages and reversed the drug-induced lengthening of action potential duration (APD).
C28 prevent or reverse the drug-induced APD prolongation back to normal while having a minimal effect on the control APD at the same concentration in healthy cardiac myocytes.
C28 also boosts the cAMP effects of KCNQ1.

物理化学性质&存储条件

分子量	416.38
分子式	C20H13N2NaO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (E)-3-hydroxy-4-((2-hydroxynaphthalen-1-yl)diazenyl)naphthalene-2-sulfonate

参考文献

1. Yangyang Lin, et al. Proc Natl Acad Sci U S A. 2021 May 18;118(20):e2024215118.

2. Hou P, et al. NAS Nexus. 2024 Oct 9;3(10):pgae452.

C28 (IKs activator C28)

生物&药学活性

物理化学性质&存储条件

参考文献

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C28 (IKs activator C28)

生物&药学活性

物理化学性质&存储条件

参考文献

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