SZV-2649 | Potassium channel activator | Probechem Biochemicals

Chemical Structure : SZV-2649

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SZV-2649 (SZV2649)

货号: PC-23125Not For Human Use, Lab Use Only.

SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects.

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生物&药学活性

SZV-2649 is a small molecule multiple ion channel inhibitor, inhibits hERG and GIRK currents in HEK cells with IC50 of 342 and 529 nM respectively, shows antiarrhythmic effects.
SZV-2649 (10 µM) decreases the densities of IKr, and Ito outward and INaL and ICaL inward currents in canine ventricular myocytes.
SZV-2649 (2.5–10 µM) elicits Class IB type Vmax reducing and Class III type action potential duration prolonging effects in dog right ventricular muscle preparations.
SZV-2649 (2.5–10 µM) moderately prolongs action potential duration in canine atrial muscle.
SZV-2649 inhibits several types of outward potassium currents including hERG/IKr and acetylcholine-activated outward potassium currents, hERG current more potently than IKr.

物理化学性质&存储条件

分子量	464.47
分子式	C10H11ClI2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-aminopropoxy)-3,5-diiodobenzonitrile hydrochloride

参考文献

1. Mohammed ASA, et al. Sci Rep. 2024 Oct 5;14(1):23188.

SZV-2649 (SZV2649)

生物&药学活性

物理化学性质&存储条件

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SZV-2649 (SZV2649)

生物&药学活性

物理化学性质&存储条件

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