Azimilide | hERG inhibitor | Probechem Biochemicals

Chemical Structure : Azimilide

CAS No.: 149908-53-2

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Azimilide (NE-10064)

货号: PC-45471Not For Human Use, Lab Use Only.

Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.

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25 mg	￥1480	In stock
50 mg	￥2480	In stock
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生物&药学活性

Azimilide (NE-10064) is a class ΙΙΙ antiarrhythmic agent that blocks hERG channel, blocks HERG channel at 0.1 and 1 Hz with IC50s of 1.4 uM and 5.2 uM respectively.
Azimilide blocks the rapidly activating component of the delayed rectifier, IKr (IC50=0.4 uM), and inhibits IKs (IC50=3 uM); shows anti-arrhythmic effects.

物理化学性质&存储条件

分子量	457.9531
分子式	C23H28ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Imidazolidinedione, 1-[[[5-(4-chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-

参考文献

1. Busch AE, et al. Br J Pharmacol. 1998 Jan;123(1):23-30.

2. Fermini B, et al. J Cardiovasc Pharmacol. 1995 Aug;26(2):259-71.

3. Walker BD, et al. Cardiovasc Res. 2000 Oct;48(1):44-58.

Azimilide (NE-10064)

生物&药学活性

物理化学性质&存储条件

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Azimilide (NE-10064)

生物&药学活性

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