PAP-1 |CAS:870653-45-5 Probechem Biochemicals

Chemical Structure : PAP-1

CAS No.: 870653-45-5

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PAP-1 (5-(4-Phenoxybutoxy)psoralen;PAP1)

货号: PC-42069Not For Human Use, Lab Use Only.

PAP-1 is a potent, selective small molecule lymphocyte K+ channel Kv1.3 blocker with EC50 of 2 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

PAP-1 is a potent, selective small molecule lymphocyte K+ channel Kv1.3 blocker with EC50 of 2 nM.
PAP-1 displays 23-fold selectivity over Kv1.5, 33- to 125-fold selectivity over other Kv1-family channels, and 500- to 7500-fold selectivity over Kv2.1, Kv3.1, Kv3.2, Kv4.2, HERG, calcium-activated K+ channels, Na+,Ca2+, and Cl- channels.
PAP-1 potently inhibits the proliferation of human TEM cells and suppresses delayed type hypersensitivity, a TEM cell-mediated reaction, in rats; orally bioavailable.

物理化学性质&存储条件

分子量	350.3646
分子式	C21H18O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenoxybutoxy)-

参考文献

1. Schmitz A, et al. Mol Pharmacol. 2005 Nov;68(5):1254-70.

2. Kundu-Raychaudhuri S, et al. J Autoimmun. 2014 Dec;55:63-72.

3. Azam P, et al. J Invest Dermatol. 2007 Jun;127(6):1419-29.

PAP-1 (5-(4-Phenoxybutoxy)psoralen;PAP1)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

PAP-1 (5-(4-Phenoxybutoxy)psoralen;PAP1)

生物&药学活性

物理化学性质&存储条件

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