VU0810464 |CAS:2126040-21-7 Probechem Biochemicals

Chemical Structure : VU0810464

CAS No.: 2126040-21-7

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VU0810464 (VU 0810464;VU464)

货号: PC-36154Not For Human Use, Lab Use Only.

VU0810464 (VU 0810464, VU464) is a selective neuronal GIRK channels activator, displays nanomolar potency for GIRK1/2 (EC50=163 nM) and improved brain penetration.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

VU0810464 (VU 0810464, VU464) is a selective neuronal GIRK channels activator, displays nanomolar potency for GIRK1/2 (EC50=163 nM) and improved brain penetration.
VU0810464 exhibits comparable efficacy and potency compared with ML297, but VU0810464 is more selective for neuronal GIRK channels (GIRK1/4 EC50>500 nM).
VU0810464 displays >3-fold more potent on GIRK1/2-expressing HEK293 cells compared to GIRK1/4-expressing cells, as measured using a Tl+ flux assay.
VU0810464 reduced stress-induced hyperthermia in a GIRK-dependent manner in mice, ML297, but not VU0810464, decreased anxiety-related behavior as assessed with the elevated plus maze test.

物理化学性质&存储条件

分子量	349.834
分子式	C18H21ClFN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-chloro-4-fluorophenyl)-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)acetamide

参考文献

1. Vo BN, et al. Br J Pharmacol. 2019 Mar 29. doi: 10.1111/bph.14671.

2. Wieting JM, et al. ACS Chem Neurosci. 2017 Sep 20;8(9):1873-1879.

VU0810464 (VU 0810464;VU464)

生物&药学活性

物理化学性质&存储条件

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VU0810464 (VU 0810464;VU464)

生物&药学活性

物理化学性质&存储条件

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