IK1 inhibitor PA-6 |CAS:500715-03-7 Probechem Biochemicals

Chemical Structure : IK1 inhibitor PA-6

CAS No.: 500715-03-7

加入收藏

IK1 inhibitor PA-6 (PA-6)

货号: PC-35388Not For Human Use, Lab Use Only.

IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

IK1 inhibitor PA-6 is an efficient, specific inhibitor of inward rectifier current (IK1), blocks KIR2.x currents of human and mouse with IC50 of 12-15 nM.
PA-6 does not affect INav1.5, ICa-L, IKv4.3, IKv11.1, and IKv7.1/minK currents at 200 nM.
PA-6 inhibits the inward (50 nM 40%; 100 nM 59%; 200 nM 77%) and outward (50 nM 40%; 100 nM 76%; 200 nM 100%) components of IK1 in isolated canine adult-ventricular cardiomyocytes.
PA-6 demonstrates higher efficiency and specificity to KIR2.x-mediated current than the antiprotozoal drug pentamidine.

物理化学性质&存储条件

分子量	492.623
分子式	C31H32N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,5-Bis[4-[[imino(phenyl)methyl]amino]phenoxy]pentane

参考文献

1. Ji Y, et al. Br J Pharmacol. 2017 Aug;174(15):2576-2590.

2. Ji Y, et al. J Biomed Sci. 2017 Jul 15;24(1):44.

3. Takanari H, et al. Cardiovasc Res. 2013 Jul 1;99(1):203-14.

4. Hoeker GS, et al. Physiol Rep. 2017 Jan;5(1). pii: e13120.

IK1 inhibitor PA-6 (PA-6)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

IK1 inhibitor PA-6 (PA-6)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.