IQM-266 | Kv4.3 inhibitor | Probechem Biochemicals

Chemical Structure : IQM-266

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IQM-266 (IQM 266, IQM266)

货号: PC-36155Not For Human Use, Lab Use Only.

IQM-266 (IQM266) is a DREAM (Downstream Regulatory Element Antagonist Modulator) ligand (Kd=4.63 uM), inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner.

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生物&药学活性

IQM-266 (IQM266) is a DREAM (Downstream Regulatory Element Antagonist Modulator) ligand (Kd=4.63 uM), inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner.
IQM-266 is a new activator of the DREAM-mediated KV4.3 currents, decreases the peak current and slowing the inactivation kinetics, increases the transmembrane charge (QKV4.3/DREAM ) at a certain range of concentrations.
IQM-266 inhibits the peak amplitude and slowed the inactivation of I A in rat dorsal root ganglion neurons.
IQM-266 is a new chemical tool that might allow a better understanding of DREAM physiological role as well as modulation of neuronal I A in pathological processes.

物理化学性质&存储条件

分子量	397.43
分子式	C25H19NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-(3-Phenoxyphenyl)acetamido)-2-naphthoic acid

参考文献

1. Peraza DA, et al. Front Mol Neurosci. 2019 Feb 4;12:11. doi: 10.3389/fnmol.2019.00011.

IQM-266 (IQM 266, IQM266)

生物&药学活性

物理化学性质&存储条件

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IQM-266 (IQM 266, IQM266)

生物&药学活性

物理化学性质&存储条件

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