GAT1508 | GIRK1/2 activator | Probechem Biochemicals

Chemical Structure : GAT1508

加入收藏

GAT1508 (GAT-1508, GAT 1508)

货号: PC-38131Not For Human Use, Lab Use Only.

GAT1508 (GAT-1508) is a potent, specific activator for brain-expressed GIRK1/2 channels (EC50=75 nM), specifically activates the brain GIRK1/2 over the cardiac GIRK1/4.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GAT1508 (GAT-1508) is a potent, specific activator for brain-expressed GIRK1/2 channels (EC50=75 nM), specifically activates the brain GIRK1/2 over the cardiac GIRK1/4.
GAT1508 is an allosteric modulator of channel–phosphatidylinositol 4,5-bisphosphate interactions.
GAT1508 effectively extinguished conditioned fear in rodents and lacked cardiac and behavioral side effects, suggesting its potential for use in pharmacotherapy for post-traumatic stress disorder.

物理化学性质&存储条件

分子量	377.26
分子式	C15H13BrN4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-Bromothiophen-2-yl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea

参考文献

1. Xu Y, et al. J Biol Chem. 2020 Mar 13;295(11):3614-3634.

GAT1508 (GAT-1508, GAT 1508)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GAT1508 (GAT-1508, GAT 1508)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.