| Cat. No. |
Product Name |
Information |
| PC-36093 |
IS-741
cPLA2 inhibitor
|
IS-741 (Fuzapladib, IS741) is a synthetic anti-inflammatory agent that shows inhibitory effect on cytosolic phospholipase A2 (cPLA2).. |
| PC-35979 |
LEI110
PLA2G16 inhibitor
|
LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6). |
| PC-35798 |
HT105
CD95-PLCγ1 inhibitor
|
HT105 (HT-105) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM. |
| PC-35797 |
DB550
CD95-PLCγ1 inhibitor
|
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM. |
| PC-35796 |
DO264
ABHD12 inhibitor
|
DO264 (DO-264) is a potent, selective, reversible and vivo-active inhibitor of ABHD12 that inhibits ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain with IC50 of 2.8 nM. |
| PC-35307 |
sPLA2-X inhibitor 31
sPLA2-X inhibitor
|
sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively. |
| PC-35258 |
ARN19874
NAPE-PLD inhibitor
|
ARN19874 (ARN-19874) is the first selective, cell-active inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) with IC50 of 33.7 uM. |
| PC-43523 |
U-73122
PLC inhibitor
|
U-73122 (U73122) is an unselective phospholipase C (PLC) inhibitor, inhibits agonist-induced platelet aggregation with IC50 of 1-5 uM. |
| PC-43510 |
Varespladib
sPLA2 inhibitor
|
Varespladib (LY315920, A-002) is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) with IC50 of 9 nM, 40-fold less active against group IB, pancreatic sPLA2 and inactive against cytosolic PLA2. |
| PC-63287 |
Edelfosine
PLC inhibitor
|
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits PLC with IC50 of 9.6 uM in fibroblasts and adenocarcinoma cells. |
| PC-43220 |
FIPI
PLD1/PLD2 inhibitor
|
FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a potent, in vivo active phospholipase D (PLD) inhibitor with IC50 of 25 nM for both PLD1 and PLD2. |
| PC-63190 |
VU0155069
PLD1 inhibitor
|
VU0155069 is a potent, selective phospholipase D1 (PLD1) inhibitor with IC50 of 46 nM, 20-fold selectivity over PLD2 (IC50=933 nM). |
