HT105 | Probechem Biochemicals

Chemical Structure : HT105

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HT105 (HT-105;HT 105)

货号: PC-35798Not For Human Use, Lab Use Only.

HT105 (HT-105) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM.

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生物&药学活性

HT105 (HT-105) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM.
HT105 exerted a potent cytotoxic effect against a large panel of tumor cell lines, unlike DB550, HT105 possesses off-target effects responsible for triggering a cell-death program in tumor cells.

物理化学性质&存储条件

分子量	958.154
分子式	C42H67N15O9S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-threonyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-histidyl-L-arginyl-L-lysine

参考文献

1. Poissonnier A, et al. Nat Chem Biol. 2018 Dec;14(12):1079-1089.

HT105 (HT-105;HT 105)

生物&药学活性

物理化学性质&存储条件

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HT105 (HT-105;HT 105)

生物&药学活性

物理化学性质&存储条件

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