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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-YM26734
YM26734

Chemical Structure : YM26734

CAS No.: 144337-18-8

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YM26734 (YM-26734)

货号: PC-38483Not For Human Use, Lab Use Only.

YM-26734 is a potent, selective and competitive inhibitor of extracellular group II phospholipase A2 (sPLA2) with IC50 of 85 nM (rabbit platelet-derived group II), >70-fold selectivity over group I PLA2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

YM-26734 is a potent, selective and competitive inhibitor of extracellular group II phospholipase A2 (sPLA2) with IC50 of 85 nM (rabbit platelet-derived group II), >70-fold selectivity over group I PLA2.
YM-26734 did not reduce the activity of intracellular PLA2 prepared from mouse macrophages, which preferentially hydrolyzed arachidonoyl phospholipids at concentrations up to 50 uM.
YM-26734 also showed no effect against either sheep seminal vesicle cyclo-oxygenase or rat leukocyte 5-lipoxygenase.
YM-26734 is a competitive inhibitor of group II PLA2 derived from rabbit platelets with Ki of 48 nM.
YM-26734 inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 mg/ear)-induced ear oedema in a dose-dependent manner, with ED50 values of 45 mg/ear and 11 mg/kg, i.v.

物理化学性质&存储条件

分子量 730.983
分子式 C45H62O8
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,1'-[5-[3,4-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone

参考文献

1. Miyake A, et al. Br J Pharmacol. 1993 Sep;110(1):447-53.

2. Miyake A, et al. Eur J Pharmacol. 1994 Feb 21;253(1-2):155-61.

3. Rodríguez Diez G, et al. Exp Eye Res. 2013 Aug;113:172-81.

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