LEI-401 | NAPE-PLD inhibitor | Probechem Biochemicals

Chemical Structure : LEI-401

CAS No.: 2393840-15-6

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LEI-401 (LEI401)

货号: PC-38219Not For Human Use, Lab Use Only.

LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
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100 mg		Get quote

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生物&药学活性

LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM.
LEI-401 does not inhibit enzymes involved in the biosynthesis and degradation of the other endocannabinoid 2-AG, DAGLα or DAGLβ, MAGL and α,β-hydrolase domain 6 (ABHD6).
LEI-401 reduced NAE levels in neuroblastoma cells and in the brain of freely moving mice, but not in NAPE-PLD KO cells and mice, respectively.
LEI-401 activated the hypothalamus-pituitary-adrenal (HPA) axis and impaired extinction of an aversive memory in mice, thereby mimicking the effects of cannabinoid CB1 receptor antagonism.

物理化学性质&存储条件

分子量	421.545
分子式	C24H31N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(cyclopropylmethyl)-6-((S)-3-hydroxypyrrolidin-1-yl)-2-((S)-3-phenylpiperidin-1-yl)pyrimidine-4-carboxamide

参考文献

1. Mock ED, et al. Nat Chem Biol. 2020 Jun;16(6):667-675.

2. Mock ED, et al. J Med Chem. 2021 Jan 14;64(1):481-515.

LEI-401 (LEI401)

生物&药学活性

物理化学性质&存储条件

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LEI-401 (LEI401)

生物&药学活性

物理化学性质&存储条件

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