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FKGK18

Chemical Structure : FKGK18

CAS No.: 1071001-09-6

FKGK18 (FKGK 18)

货号: PC-36138Not For Human Use, Lab Use Only.

FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FKGK18 (FKGK-18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM.
FKGK18 displays 195 and >455 times more potent for GVIA iPLA(2) than for GIVA cPLA(2) and GV sPLA(2).
FKGK18 inhibits Ca2+-independent PLA2 activity in a concentration-dependent manner, similar to S-BEL, which preferentially inhibits cytosol-associated iPLA2β.
FKGK18 a valuable tool to explore the role of GVIA iPLA(2) in cells and in vivo models.

物理化学性质&存储条件

分子量 280.29
分子式 C16H15F3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,1,1-trifluoro-6-(naphthalen-2-yl)hexan-2-one

参考文献

1. Kokotos G, et al. J Med Chem. 2010 May 13;53(9):3602-10.

2. Ali T, et al. PLoS One. 2013 Aug 20;8(8):e71748.

3. Bone RN, et al. Diabetes. 2015 Feb;64(2):541-54.

4. Dedaki C, et al. J Med Chem. 2019 Mar 12. doi: 10.1021/acs.jmedchem.8b01216.

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