DB550 |CAS 2362518-44-1 Probechem Biochemicals

Chemical Structure : DB550

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DB550 (DB-550;DB 550)

货号: PC-35797Not For Human Use, Lab Use Only.

DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.

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生物&药学活性

DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.
DB550 abrogates the binding of PLCγ1 to CD95 in cells exposed to s-CD95L, inhibits the CD95-mediated Ca2+ response in a similar manner in Th17 cells to minCID and preventes Th17 trafficking across endothelial cells, does not affect the CD95-mediated apoptotic signaling pathway.
DB550 abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 68 nM, alleviates clinical symptoms in lupus-prone mice.

物理化学性质&存储条件

分子量	1011.307
分子式	C43H82N18O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-amino-N-(2-((S)-2-(N-(2-((2S,3R)-2-amino-3-hydroxybutanamido)ethyl)-3-mercaptopropanamido)-5-guanidinopentanamido)ethyl)-N-((S)-1-((2-(N-((S)-1,6-diamino-1-oxohexan-2-yl)-5-guanidinopentanamido)ethyl)amino)-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)hexanamide

参考文献

1. Poissonnier A, et al. Nat Chem Biol. 2018 Dec;14(12):1079-1089.

DB550 (DB-550;DB 550)

生物&药学活性

物理化学性质&存储条件

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DB550 (DB-550;DB 550)

生物&药学活性

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