AK106-001616 |CAS:590416-75-4 Probechem Biochemicals

Chemical Structure : AK106-001616

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AK106-001616 (AK 106-001616)

货号: PC-36162Not For Human Use, Lab Use Only.

AK106-001616 (AK 106-001616) is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) with IC50 of 3.8 nM (human cPLA2 enzyme).

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生物&药学活性

AK106-001616 (AK 106-001616) is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) with IC50 of 3.8 nM (human cPLA2 enzyme).
AK106-001616 also inhibited rat cPLA2 with IC50 of 4.3 nM, shows no significant activity against human iPLA2, bovine sPLA2 IB and PAF-AH (>10,000 fold selectivity).
AK106-001616 suppressed the release of AA from Ca2+ ionophore A23187-stimulated rat RBL-2H3 cells (IC50=5.5 nM), also suppressed the production of PGE2 by LPS-stimulated human PBMCs (IC50=5.1 nM) and the production of LTB4 by Ca2+ ionophore A23187-stimulated RBL-2H3 cells (IC50=2.6 nM).
AK106-001616 demonstrates in vivo efficacy for inflammation, neuropathic pain, and pulmonary fibrosis.

物理化学性质&存储条件

分子量	427.504
分子式	C26H25N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-amino-4-((2,3-dihydro-1H-inden-2-yl)oxy)-5-(1-methyl-1H-indazol-5-yl)phenyl)propanoic acid

参考文献

1. Shimizu H, et al. J Pharmacol Exp Ther. 2019 Apr 10. pii: jpet.118.255034.

AK106-001616 (AK 106-001616)

生物&药学活性

物理化学性质&存储条件

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AK106-001616 (AK 106-001616)

生物&药学活性

物理化学性质&存储条件

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