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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-LEI110
LEI110

Chemical Structure : LEI110

CAS No.: 2313525-90-3

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LEI110 (LEI-110;LEI 110)

货号: PC-35979Not For Human Use, Lab Use Only.

LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6).

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10 mg ￥3680 In stock
25 mg ￥5680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6).
LEI110  reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells.
LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT).

物理化学性质&存储条件

分子量 456.465
分子式 C25H23F3N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-oxo-5-phenyl-N-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenethyl)pentanamide

参考文献

1. Zhou J, et al. ACS Chem Biol. 2019 Jan 8. doi: 10.1021/acschembio.8b00969.

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