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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phospholipase-VU0359595
VU0359595

Chemical Structure : VU0359595

CAS No.: 1246303-14-9

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VU0359595 (VU 0359595, ML270)

货号: PC-72954Not For Human Use, Lab Use Only.

VU0359595 (VU 0359595) is a potent, selective phospholipase D (PLD) inhibitor with cell IC50 of 4 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VU0359595 (VU 0359595, ML-270) is a potent, selective phospholipase D1 (PLD1) inhibitor with cell IC50 of 4 nM, >1700-fold selective for PLD1 over PLD2.

物理化学性质&存储条件

分子量 497.4
分子式 C25H29BrN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1R,2R)-N-[(1S)-2-[4-(5-bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-phenyl-cyclopropanecarboxamide

参考文献

1. Burkhardt U, et al. Neuropharmacology. 2014 Apr;79:1-9.

2. Burkhardt U, et al. Eur J Pharmacol. 2015 Aug 15;761:398-404.

3. Chaves-Moreira D, et al. J Cell Biochem. 2017 Apr;118(4):726-738.

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