| Cat. No. |
Product Name |
Information |
| PC-22779 |
BMS-986121
MOR PAM
|
BMS-986121 is a positive allosteric modulator of μ-opioid receptor (MOR) with EC50 of 1 uM for increased β-arrestin recruitment by 20 nM endomorphin-I. |
| PC-22777 |
DAMGO
MOR agonist
|
DAMGO is a highly affinity, selective peptide agonist of mu-opioid receptor (MOR) with Kd of 3.46 nM. |
| PC-22776 |
BPRMU191
MOR modulator
|
BPRMU191 is a unique mu-opioid receptor (MOR) modulator with EC50 of 2.17 uM in FLIPR Ca2+ assay using CHO-K1/MOR/Gα15 cells, BPRMU191 binds to MOR in the presence of naloxone. |
| PC-22594 |
µOR inhibitor 368
δ-opioid receptor NAM
|
µOR inhibitor 368 (µOR NAM 368, Compound 368) is a potent, negative allosteric modulator (NMA)/inhibitor of µ-opioid receptor (µOR), significantly inhibits met-enkephalin-induced µOR activation of Gi, increases binding of 3H-naloxone with EC50 of 133 nM. |
| PC-22000 |
LY2444296
KOR inhibitor
|
LY2444296 is a potent, selective orally bioavailable, and short-acting kappa opioid receptor (KOPR) antagonist with Ki of 1 nM. |
| PC-21949 |
Sunobinop
NOP agonist
|
Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM. |
| PC-21793 |
LY2817412
NOP antagonist
|
LY2817412 is a potent, selective andorally active nociceptin/orphanin FQ (NOP) receptor antagonist with Ki of 0.176 nM, Kb of 0.273 nM in functional assay of receptor-mediated G-protein activation using [35S]-GTPγS binding. |
| PC-21712 |
PIPE-3297
KOR agonist
|
PIPE-3297 is a fully efficacious and selective kappa opioid receptor (KOR) agonist with functional GTPγS EC50 of 1.1 nM, Emax=91%, does not elicit β-arrestin-2 recruitment functional response. |
| PC-21574 |
ZYKR1
KOR agonist
|
ZYKR1 is a potent, and peripherally restricted kappa opioid receptor (KOR)-selective agonist with EC50 of 0.061 nM in cAMP assays, highly selective over the mu and delta opioid receptors (EC50>10 μM). |
| PC-20520 |
LY255582
Pan-opioid antagonist
|
LY255582 is a potent, pan-opioid antagonist with Ki value of for 0.4 nM, 5.2 nM and 2.0 nMmu, delta, and kappa receptors, respectively, decreases short- and long-term food intake in rats. |
| PC-20510 |
AT-076
Pan opioid antagonist
|
AT-076 (AT076) is the first potent small-molecule opioid pan antagonist with receptor binding Ki values of 1.75, 1.14, 1.67 and 19.6 nM for NOP, KOP, MOP, and DOP, respectively. |
| PC-47497 |
D-Ala2, D-Leu5-Enkephalin
|
An angiotensin II analog that is an agonist of AT1 angiotensin receptor.. |
