JDTic dihydrochloride |CAS:785835-79-2 Probechem Biochemicals

Chemical Structure : JDTic dihydrochloride

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JDTic dihydrochloride

货号: PC-42615Not For Human Use, Lab Use Only.

A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM.

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生物&药学活性

A highly potent and selective kappa Opioid receptor (KOR) antagonist with Ki of 0.3 nM; has a Ki of 0.006 nM in GTP-gamma-S assay, displays >15,000-fold selectivity over delta receptors; exhibits anxiolytic-like effects in models of unlearned and learned fear in rats.

物理化学性质&存储条件

分子量	538.5494
分子式	C28H41Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Isoquinolinecarboxamide, 1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-, hydrochloride (1:2), (3R)-

参考文献

1. Thomas JB, et al. J Med Chem. 2001 Aug 16;44(17):2687-90.

2. Carroll I, et al. Eur J Pharmacol. 2004 Oct 6;501(1-3):111-9.

3. Beardsley PM, et al. Psychopharmacology (Berl). 2005 Nov;183(1):118-26.

4. Knoll AT, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):838-45.