| Cat. No. |
Product Name |
Information |
| PC-35296 |
BU09059
KOR antagonist
|
BU09059 is a potent, selective, short-acting kappa-opioid receptor antagonist with Ki of 1.72 nM, displays 15- and 616-fold selectivity over μ- and δ-receptors respectively. |
| PC-35217 |
Cebranopadol
ORL1 agonist
|
Cebranopadol (GRT-6005, GRT6005) is a potent analgesic nociceptin/orphanin FQ peptide (NOP receptor, ORL1) and opioid receptor agonist with Ki/EC50 of 0.9/13 nM (human NOP receptor), 0.7/1.2 nM (mu-opioid receptor). |
| PC-43402 |
BAN ORL 24
ORL1 inhibitor
|
BAN ORL 24 is a potent, selective, non-peptide nociceptin/orphanin FQ receptor (NOP receptor, ORL1) antagonist with IC50 of 0.27 nM, displays no significant activity for κ-, μ- and δ-receptors. |
| PC-43352 |
ADL5859
DOR agonist
|
ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor (DOR) with Ki of 0.84 nM and EC50 of 20 nM. |
| PC-42356 |
PZM21
MOR agonist
|
PZM21 is a potent, selective Gi-biased μ-opioid-receptor (μOR, MOR) agonist with Ki/EC50 of 1.1/4.6 nM, has little to no detectable κOR/δOR agonist or nociceptin receptor agonist activity. |
| PC-63082 |
BMS-986187
δ-opioid receptor modulator
|
BMS-986187 is a novel potent, positive allosteric modulator of δ-opioid receptor (DOR) with EC50 of 30 nM, 100-fold selectivity over μ-opioid receptor. |
| PC-63080 |
BMS-986122
μ-opioid receptor modulator
|
BMS-986122 is a potent positive allosteric modulator of μ-opioid (MOR) receptor, significantly increases the inhibition of forskolin-stimulated adenylyl cyclase activity produced by an EC10 (30 pM) concentration of endomorphin-I in CHO-μ cells. |
| PC-62626 |
JTC-801
ORL1 agonist
|
JTC-801 is a highly potent, selective, orally active NOP receptor (ORL1) antagonist with Ki of 8.2 nM, shows 12.5-, 129- and 1055-fold selectivity over human μ-, κ- and δ-opioid receptors respectively. |
| PC-62146 |
CYM51010
OPRM1-OPRD1 agonist
|
CYM51010 (ML335) is an agonist probe for opioid receptor mu 1 (OPRM1)-opioid receptor delta 1 (OPRD1) heterodimerization with EC50 of 403 nM. |
| PC-62111 |
ML350
KOR antagonist
|
ML350 (CYM 50202) is a highly potent and selective Opioid kappa receptor (OPRK1/KOR) antagonist with IC50 of 9-16 nM. |
| PC-62110 |
Aticaprant
KOR antagonist
|
LY 2456302 (CERC-501, JSPA 0658, Aticaprant) is a potent, selective, short-acting antagonist of κ-opioid receptor (KOR) with Ki of 0.81 nM. |
| PC-62109 |
PF-04455242 hydrochloride
KOR antagonist
|
PF-04455242 hydrochloride is a potent, selective κ-opioid receptor (KOR) antagonist with Ki of 3 nM/21 nM/22 nM for hKOR/rKOR/mKOR, respectively. |
