Sunobinop

Chemical Structure : Sunobinop

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货号: PC-21949Not For Human Use, Lab Use Only.

Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM.

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生物&药学活性

Sunobinop is a potent and partial agonist of the nociceptin/orphanin FQ peptide receptor (NOP receptor) with Ki of 3.3 nM, EC50 of 4.03 nM.
Sunobinop competitively inhibited [3H]-NOP-1A binding in rat-brain sections with IC50 of 7.7 nM.
Sunobinop does not activate human μ and κ receptors and is a low-affinity, weak partial agonist at human δ receptors.
Sunobinop promotes non-REM sleep in rodents and patients with insomnia.

物理化学性质&存储条件

分子量	435.57
分子式	C26H33N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Quinoxalinecarboxylic acid, 4-[(3-endo)-9-(3-exo)-bicyclo[3.3.1]non-3-yl-9-azabicyclo[3.3.1]non-3-yl]-3,4-dihydro-3-oxo-

参考文献

1. Whiteside GT, et al. J Clin Invest. 2024 Jan 2;134(1):e171172.

Sunobinop

生物&药学活性

物理化学性质&存储条件

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Sunobinop

生物&药学活性

物理化学性质&存储条件

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