MP135 | μ-δ opioid agonist | Probechem Biochemicals

Chemical Structure : MP135

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MP135 (MP-135)

货号: PC-49035Not For Human Use, Lab Use Only.

MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity.

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生物&药学活性

MP135 is a potent, μ-δ opioid receptor heteromer-selective agonist with EC50 of 0.8 nM in GTPγS assays, shows functional selectivity for μ-δ heteromers over homomeric μOR and δOR and low β-arrestin2 recruitment activity.
MP135 is a poor recruiter of β-arrestin2 at μ-δ heteromers (EC50=162 nM).
MP135 shows selectivity for μ-δ heteromers both ex vivo as well as in vivo and retains in vivo antinociceptive efficacy similar to morphine in rodents.

物理化学性质&存储条件

分子量	515.673
分子式	C32H38FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N-Benzylpropionamido)-N-(3-fluorophenethyl)-1-phenethyl-piperidine-4-carboxamide

参考文献

1. Faouzi A, et al. J Med Chem. 2020 Nov 25;63(22):13618-13637.

MP135 (MP-135)

生物&药学活性

物理化学性质&存储条件

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MP135 (MP-135)

生物&药学活性

物理化学性质&存储条件

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