RM1490 | MOR agonist | Probechem Biochemicals

Chemical Structure : RM1490

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RM1490 (RM 1490)

货号: PC-49745Not For Human Use, Lab Use Only.

RM1490 (RM 1490) is a potent, brain-penetrant µ opioid receptor (MOR) agonist with EC50 of 3.4 and 4.4 nM in GTPγS and cAMP assays, respectively.

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生物&药学活性

RM1490 (RM 1490) is a potent, brain-penetrant µ opioid receptor (MOR) agonist with EC50 of 3.4 and 4.4 nM in GTPγS and cAMP assays, respectively.
RM1490 inhibits the cAMP response to DAMGO in competition assays.
RM1490 exhibits approximately half the intrinsic MOR efficacy of buprenorphine.
RM1490 (3 mg/kg) dose-dependently reduces the number of writhes in acetic acid–induced writhing.
RM1490 has a physiological and behavioral profile suitable for opioid use disorder maintenance therapy.

物理化学性质&存储条件

分子量	394.56
分子式	C25H34N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-cyclopropyl-N-((S)-2-(dimethylamino)-3-(4-hydroxy-2,6-dimethylphenyl)propyl)-3-phenylpropanamide

参考文献

1. Beth Youngblood, et al. J Pharmacol Exp Ther. 2021 Aug;378(2):133-145.

RM1490 (RM 1490)

生物&药学活性

物理化学性质&存储条件

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RM1490 (RM 1490)

生物&药学活性

物理化学性质&存储条件

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