SLL-022CCP

Chemical Structure : SLL-022CCP

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货号: PC-27169Not For Human Use, Lab Use Only.

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生物&药学活性

SLL-022CCP is a potent, selective κ-opioid receptor (KOR) agonist with EC50 of 0.002 nM for inhibiting cAMP production, exhibits high receptor subtype selectivity over μ-opioid receptor (MOR, EC50=1.6 nM) and δ-opioid receptor (DOR, EC50=30.0 nM).
SLL-022CCP recruited β-arrestin at the KOR with an EC50 of 15.5 nM and at the MOR with an EC50 of 668.0 nM.
SLL-022CCP produced potent antinociception in the hot plate test (ED50 = 1.816 mg/kg), acetic acid-induced writhing test (ED50 = 0.113 mg/kg), and significant antipruritic effects in the histamine-induced itch test (ED50 = 0.079 mg/kg) and CFA-induced itch test (ED50 = 0.105 mg/kg).
SLL-022CCP exhibits robust antinociceptive and antipruritic effects with low central side effects.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Gui JW, et al. ACS Omega. 2026 Jun 4;11(24):36322-36336.

SLL-022CCP

生物&药学活性

物理化学性质&存储条件

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SLL-022CCP

生物&药学活性

物理化学性质&存储条件

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