MCOPPB trihydrochloride

Chemical Structure : MCOPPB trihydrochloride

CAS No.: 1108147-88-1

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货号: PC-26682Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MCOPPB trihydrochloride is potent, selective nociceptin/orphanin FQ peptide receptor (NOP receptor) with pKi of 10.07, shows 12-, 270- and >1000-fold selectivity over opioid receptors micro-, kappa-, and delta-receptor, respectively.
MCOPPB (10 mg/kg, p.o.) inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered.
MCOPPB (10 mg/kg, p.o.) and diazepam (3 mg/kg, p.o.) elicited anxiolytic-like effects in mouse Vogel conflict test.
MCOPPB at an oral dose of 10 mg/kg did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.

物理化学性质&存储条件

分子量	518.01
分子式	C26H43Cl3N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(1-(1-methylcyclooctyl)piperidin-4-yl)-2-(piperidin-3-yl)-1H-benzo[d]imidazole trihydrochloride

参考文献

1. Hirao A, et al. J Pharmacol Sci. 2008 Mar;106(3):361-8.