| Cat. No. |
Product Name |
Information |
| PC-72429 |
AXT107
VEGFR2-β3 inhibitor
|
AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation. |
| PC-72274 |
GSK3335103
αvβ6 inhibitor
|
GSK3335103 (GSK-3335103) is a potent, oral, small molecule RGD-mimetic αvβ6 integrin inhibitor with pKi of 9.96. |
| PC-35719 |
Valategrast hydrochloride
Integrin α4β1/α4β7 inhibitor
|
Valategrast (R411) hydrochloride is a potent, α4β1 (VLA-4) and α4β7 dual antagonist, shows potential for Chronic obstructive pulmonary disease (COPD) and asthma. |
| PC-35718 |
Valategrast
Integrin α4β1/α4β7 inhibitor
|
Valategrast (R411) is a potent, α4β1 (VLA-4) and α4β7 dual antagonist, shows potential for chronic obstructive pulmonary disease (COPD) and asthma. |
| PC-35693 |
SC-68448
Integrin αvβ3 inhibitor
|
SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3. |
| PC-35657 |
AJM300
α4 integrin inhibitor
|
AJM300 (Carotegrast methyl, AJM-300) is a novel potent, selective, oraaly available alpha 4 integrin antagonist fortreatment of active ulcerative colitis. |
| PC-35546 |
BIO1211
Integrin α4β1 (VLA-4) inhibitor
|
BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1. |
| PC-35545 |
DS-70
Integrin α4β1 inhibitor
|
DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity. |
| PC-35165 |
Risuteganib
Integrin inhibitor
|
Risuteganib (ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis. |
| PC-35164 |
SF0166
αvβ3 integrin inhibitor
|
SF0166 (Nesvategrast, SF-0166) is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8. |
| PC-35072 |
ER-464195-01
Calreticulin-Integrin α inhibitor
|
ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5. |
| PC-35035 |
BI-1950
LFA-1 inhibitor
|
BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM. |
