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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-Cilengitide
Cilengitide

Chemical Structure : Cilengitide

CAS No.: 188968-51-6

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Cilengitide (EMD 121974)

货号: PC-73164Not For Human Use, Lab Use Only.

Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively.

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25 mg ￥3480 In stock
100 mg ￥8480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively.
Cilengitide increases endothelial monolayer permeability, exhibits antiangiogenic activity.
Cilengitide synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts.

物理化学性质&存储条件

分子量 588.666
分子式 C27H40N8O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

Chemical Name/SMILES

参考文献

1. Burke PA, et al. Cancer Res. 2002 Aug 1;62(15):4263-72.

2. Taga T, et al. Int J Cancer. 2002 Apr 10;98(5):690-7.

3. Lode HN, et al. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1591-6.

4. Dechantsreiter MA, et al. J Med Chem. 1999 Aug 12;42(16):3033-40.

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