C67399 | TLN1-integrin β1 inhibitor | Probechem Biochemicals

Chemical Structure : C67399

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C67399 (C 67399)

货号: PC-73352Not For Human Use, Lab Use Only.

C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM).

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生物&药学活性

C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM).
C67399 treatment significantly reduced the viability of BT549 cells.
C67399 (2 uM) significantly reduced the expression of integrin β1, AKT, FAK, and phosphorylated FAK in MDA-MB-231 cells, while did not affect the expression of integrin β3.
C67399 inhibited the binding of TLN1 to integrin β1 in MDA-MB-231 cells.
C67399 (1.75 mg/kg) inhibited tumour growth and metastasis of MDA-MB-231 cells in mice, without causing obvious structural toxic changes.

物理化学性质&存储条件

分子量	584.797
分子式	C38H48O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,5R,8S,9R,10R,13R,14R,17R)-17-((S)-1-acetoxyethyl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl 2-(4-benzoylphenyl)acetate

参考文献

1. Yixiao Zhang, et al. Elife. 2022 Mar 14;11:e68481.

C67399 (C 67399)

生物&药学活性

物理化学性质&存储条件

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C67399 (C 67399)

生物&药学活性

物理化学性质&存储条件

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