| Cat. No. |
Product Name |
Information |
| PC-49394 |
EMD527040
αvβ6 antagonist
|
EMD527040 (EMD 527040) is a potent, specific, nonpeptidic inhibitor of αvβ6 integrin, inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins. |
| PC-49346 |
TBC4746
VLA-4 inhibitor
|
TBC 4746 (AVA4746) is a small molecule mimetic of VCAM-1 that binds VLA-4 on B-ALL cells with high affinity and efficiently blocks ligand-binding with VCAM-1 with EC50 of 38.52 nM. |
| PC-49345 |
IVL745
VLA-4 inhibitor
|
IVL745 (IVL-745) is a small molecule very late antigen (VLA-4) antagonist with IC50 of 20 nM and 2 nM for adhesion to VCAM-1 and fibronectin, respectively. |
| PC-49182 |
GW559090
VLA-4 inhibitor
|
GW559090 is a potent, selective, competitive and high-affinity α4β1 integrin (VLA-4) antagonist with Kd of 0.19/1.04 nM for huamn/rat α4β1, respectively. |
| PC-38812 |
THI0019
Integrin α4β1 agonist
|
THI0019 is a small molecule agonist of the integrin α4β1 (very late antigen-4 or VLA-4) with EC50 of 1.7 uM in cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA. |
| PC-38811 |
7HP349
LFA-1 activator
|
Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response. |
| PC-38443 |
A-286982
LFA-1/ICAM-1 inhibitor
|
A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50 of 44 and 35 nM in LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively. |
| PC-73406 |
Bexotegrast
αvβ6/αvβ1 integrin inhibitor
|
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. |
| PC-73352 |
C67399
TLN1-integrin β1 inhibitor
|
C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM). |
| PC-73252 |
BIRT-377
LFA-1 inhibitor
|
BIRT-377 (BIRT377) is a potent, orally active negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) with Kd of 26 nM. |
| PC-73164 |
Cilengitide
Integrin inhibitor
|
Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively. |
| PC-72987 |
ADH-503
CD11b agonist
|
ADH-503 (GB1275, Leukadherin-1 choline) is a small-molecule allosteric agonist of CD11b that can render tumors more sensitive to checkpoint blockade. |
