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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-EMD527040
EMD527040

Chemical Structure : EMD527040

CAS No.: 851333-14-7

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EMD527040 (EMD 527040)

货号: PC-49394Not For Human Use, Lab Use Only.

EMD527040 (EMD 527040) is a potent, specific, nonpeptidic inhibitor of αvβ6 integrin, inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    EMD527040 (EMD 527040) is a potent, specific, nonpeptidic inhibitor of αvβ6 integrin, inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins.
    EMD527040 attenuated bile ductular proliferation and peribiliary collagen deposition by 40%-50%, induced down-regulation of fibrogenic and up-regulation of fibrolytic genes, and improved liver architecture and function.
    EMD527040 reduced activated cholangiocyte proliferation, their adhesion to fibronectin, and endogenous activation of TGF-beta1 by 50% but did not affect bile duct apoptosis.
    EMD527040 reduced expression of profibrotic markers and reduced fibrosis formation in DSG2-W2A mutation in arrhythmogenic cardiomyopathy (ACM) animal model.

    物理化学性质&存储条件

    分子量 587.498
    分子式 C29H32Cl2N4O5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-{(S)-3-Benzyloxy-2-[5-(pyridin-2-ylamino)-pentanoylamino]-propionylamino}-3-(3,5-dichloro-phenyl)-propionic acid

    参考文献

    1. Goodman SL, et al. J Med Chem. 2002;45:1045-1051.

    2. Patsenker E, et al. Gastroenterology. 2008 Aug;135(2):660-70.

    3. Camilla Schinner, et al. Circulation. 2022 Oct 21. doi: 10.1161/CIRCULATIONAHA.121.057329.

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