6-B345TTQ

Chemical Structure : 6-B345TTQ

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货号: PC-49780Not For Human Use, Lab Use Only.

6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration.

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生物&药学活性

6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration.
6-B345TTQ did not inhibited the interaction of leupaxin with the FAT sequence of pp125FAK at 100 uM.
6-B345TTQ inhibited α4-mediated monocyte and T cell migration by 52.6% and 56.4%, respectively, but did not significantly reduce T cell migration mediated by other α integrin subunits.
6-B345TTQ inhibited the interaction of paxillin with FAT and Git-1 (IC50=24 uM).
6-B345TTQ (40 uM) increases α4-dependent cell spreading in Jurkat T cells and CHO cells.
6-B345TTQ (16.5 mg/kg, sterile 4% (w/v) thioglycollate, i.p.) impaired the recruitment of mononuclear leukocytes to the peritoneum in response to thioglycollate in C57BL/6 mice.

物理化学性质&存储条件

分子量	442.31
分子式	C22H20BrNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Bromo-3,4-dihydro-4-(3,4,5-trimethoxyphenyl)-benzo[h]quinolin-2(1H)-one

参考文献

1. Kummer C, et al. J Biol Chem. 2010 Mar 26;285(13):9462-9469.

6-B345TTQ

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物理化学性质&存储条件

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6-B345TTQ

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