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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-QLT0267
QLT0267

Chemical Structure : QLT0267

CAS No.: 866409-68-9

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QLT0267 (QLT-0267)

货号: PC-49560Not For Human Use, Lab Use Only.

QLT-0267 (QLT0267) is a potent, selective inhibitor of integrin-linked kinase (ILK), inhibits the kinase activity of ILK in cell-free assay at 26 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    QLT-0267 (QLT0267) is a potent, selective inhibitor of integrin-linked kinase (ILK), inhibits the kinase activity of ILK in cell-free assay at 26 nM.
    QLT0267 inhibited cell growth in thyroid cancer cell lines with an mean IC50 of 3 uM.
    QLT0267 inhibits the kinase activity of ILK in cell-free assay at 26 nmol/L and shows 1,000-fold selectivity over other kinases, including CK2, CSK, DNA-PK, PIM1, protein kinase B or AKT kinase, and PKC, 100-fold selectivity over extracellular signal-regulated kinase 1, GSK3β, LCK, PKA, p70S6K, and RSK1.
    QLT0267 inhibits cell growth, proliferation, and induction of apoptosis in thyroid cancer cell lines.
    QLT0267 inhibits epidermal growth factor-induced phosphorylation of AKT in Hth74 cells.
    QLT0267 (50 and 100 mg/kg) induces tumor growth inhibition on DRO thyroid cancer xenografts, inhibits the phosphorylation of AKT and induces apoptosis in vivo.
    QLT0267 also reduces mean vascular density (MVD) of tumor and induces apoptosis of tumor-associated endothelial cells.

    物理化学性质&存储条件

    分子量 232.25
    分子式 C10H12N6O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-(4-methoxyphenyl)hydrazineylidene)-4H-pyrazole-3,5-diamine

    参考文献

    1. Younes MN, et al. Mol Cancer Ther. 2005 Aug;4(8):1146-56.

    2. Koul D, et al. Mol Cancer Ther. 2005 Nov;4(11):1681-8.

    3. Troussard AA, et al. Cancer Res. 2006 Jan 1;66(1):393-403.

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