Alintegimod (7HP349) | LFA-1 activator | Probechem Biochemicals

Chemical Structure : 7HP349

加入收藏

7HP349 (Alintegimod)

货号: PC-38811Not For Human Use, Lab Use Only.

Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response.
7HP349 increases tumor-specific T cell activation and localization to a non-T cell inflamed cold tumor microenvironment typically characterized by low ICAM-1 expression and enhances the anti-tumor activity of CTLA-4 and PD-1/L1.
7HP349 monotherapy had modest effects on anti- programmed death 1 (PD-1)-resistant tumors, whereas combinatorial treatment with anti- T-lymphocyte-associated protein 4 (CTLA-4) therapy increased CD8+ Teff intratumoral sequestration and synergized in inducing cancer regression, in cooperation with neutrophils.

物理化学性质&存储条件

分子量	620.812
分子式	C28H32N2O6S4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl) bis(bis(thiophen-2-ylmethyl)carbamate)

参考文献

1. Hickman A, et al. J Clin Invest. 2022 May 12:e154152.

2. Lokugamage N, et al. NPJ Vaccines. 2021 Sep 8;6(1):114.

7HP349 (Alintegimod)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

7HP349 (Alintegimod)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.