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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-E7820
E7820

Chemical Structure : E7820

CAS No.: 289483-69-8

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E7820 (E-7820)

货号: PC-20146Not For Human Use, Lab Use Only.

E7820 (E-7820) is a unique, oral sulfonamide derivative angiogenesis inhibitor, inhibits integrin α2 (ITGA2) mRNA expression and suppresses tube formation through the suppression of integrin alpha2.

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10 mg ￥980 In stock
25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

E7820 (E-7820) is a unique, oral sulfonamide derivative angiogenesis inhibitor, inhibits integrin α2 (ITGA2) mRNA expression and suppresses tube formation through the suppression of integrin alpha2.
E7820 inhibited in vitro proliferation and tube formation of human umbilical vascular endothelial cell (HUVEC).
E7820 decreased integrin alpha2, 3, 5, and beta1 in confluent culture of HUVEC, and integrin alpha2 was initially suppressed in mRNA level, followed by decrement of integrins alpha3, 5, and beta1.
E7820 reduced integrin alpha2 expression on a megakaryocytic cell line, Dami cells, induced by phorbol 12-myristate 13-acetate treatment.
Oral administration of E7820 significantly inhibited basic fibroblast growth factor-induced angiogenesis in Matrigel implants and human colon WiDr tumor-induced angiogenesis in a dorsal air sac model.
E7820 showed a broad-spectrum antitumor effect in mice through inhibition of angiogenesis.

物理化学性质&存储条件

分子量 336.37
分子式 C17H12N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide

参考文献

1. Yasuhiro Funahashi, et al. Cancer Res. 2002 Nov 1;62(21):6116-23.

2. Hülskamp MD, et al. BMC Cancer. 2021 May 18;21(1):571.

3. Semba T, et al. Clin Cancer Res. 2004 Feb 15;10(4):1430-8.

4. Mita M, et al. Clin Cancer Res. 2011 Jan 1;17(1):193-200.

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