| Cat. No. |
Product Name |
Information |
| PC-27662 |
AJM347
α4β7 integrin antagonist
|
AJM347 is a potent, selective and orally active α4β7 integrin antagonist, inhibits the binding of immune cells expressing α4β7 integrin to gastrointestinal submucosa, while not interacting with cells expressing α4β1 integrin. |
| PC-27517 |
Zotemtegrast
α4β7 integrin inhibitor
|
Zotemtegrast (LY4268989, MORF-057) is a selecitve, orally bioavailable of alpha4beta7 integrin (α4β7 integrin), inhibits α4β7 integrin-mediated recruitment of α4β7-expressing lymphocytes to the gut. |
| PC-25046 |
Emvistegrast
α4β7 integrin inhibitor
|
Emvistegrast (GS-1427) is an oral prodrug that is rapidly converted to the active species GS-1069518, a potent and selective α4β7 integrin inhibitor. |
| PC-23935 |
Integrin α5β1 inhibitor MRT1
Integrin α5β1 inhibitor
|
Integrin α5β1 inhibitor MRT1 is a specific small molecule inhibitor of RGD (arginylglycylaspartic acid)-binding integrin α5β1 with IC50 of 40 nM in fluorescence polarization assays, and IC50 of 18 and 54 nM for other RGD binding β1 integrins αvβ1 and α8β1. |
| PC-23275 |
MORF-627
αvβ6 integrin inhibitor
|
MORF-627 is a highly selective inhibitor of integrin αvβ6 with IC50 of 1.1 nM, >300-fold selective over αvβ1 and αvβ8. |
| PC-21536 |
ATN-161 TFA salt
Integrin α5β1/αvβ3 inhibitor
|
ATN-161 TFA salt (Ac-PHSCN-NH2) is a small peptide inhibitor of integrin alpha5 beta1 (α5β1) and alphavbeta3 (αvβ3) with binding Kd of 1.0 and 0.6 uM, respectively, inhibits breast cancer growth and metastasis. |
| PC-21535 |
ATN-161
Integrin α5β1/αvβ3 inhibitor
|
ATN-161 (Ac-PHSCN-NH2) is a small peptide inhibitor of integrin alpha5 beta1 (α5β1) and alphavbeta3 (αvβ3) with binding Kd of 1.0 and 0.6 uM, respectively, inhibits breast cancer growth and metastasis. |
| PC-20146 |
E7820
Integrin α2 inhibitor
|
E7820 (E-7820) is a unique, oral sulfonamide derivative angiogenesis inhibitor, inhibits integrin α2 (ITGA2) mRNA expression and suppresses tube formation through the suppression of integrin alpha2. |
| PC-49804 |
MSR03
αVβ3 inhibitor
|
MSR03 is a potent, pure small molecule αVβ3 antagonist with IC50 of 1.5 uM for inhibition of adhesion of cells expressing human αVβ3 to immobilized fibrinogen. |
| PC-49784 |
A7B7C7
Integrin α4β1 inhibitor
|
A7B7C7 (11-A7B7C7) is a potent Paxillin-α4 integrin binding antagonist with IC50 of 300 nM in vitro, decreases α4β1-mediated T cell migration. |
| PC-49780 |
6-B345TTQ
α4 integrin-paxillin inhibitor
|
6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration. |
| PC-49560 |
QLT0267
ILK inhibitor
|
QLT-0267 (QLT0267) is a potent, selective inhibitor of integrin-linked kinase (ILK), inhibits the kinase activity of ILK in cell-free assay at 26 nM. |
