ATN-161 TFA salt | Integrin α5β1/αvβ3 inhibitor | Probechem Biochemicals

Chemical Structure : ATN-161 TFA salt

CAS No.: 904763-27-5

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ATN-161 TFA salt (Ac-PHSCN-NH2, ATN161)

货号: PC-21536Not For Human Use, Lab Use Only.

ATN-161 TFA salt (Ac-PHSCN-NH2) is a small peptide inhibitor of integrin alpha5 beta1 (α5β1) and alphavbeta3 (αvβ3) with binding Kd of 1.0 and 0.6 uM, respectively, inhibits breast cancer growth and metastasis.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

ATN-161 TFA salt (Ac-PHSCN-NH2) is a small peptide inhibitor of integrin alpha5 beta1 (α5β1) and alphavbeta3 (αvβ3) with binding Kd of 1.0 and 0.6 uM, respectively, inhibits breast cancer growth and metastasis.
ATN-161 forms a disulfide bond with its integrin target.
ATN-161 (20 uM) significantly inhibits MAPK phosphorylation with maximal effects in MDA-MB-231 cells.
ATN-161 (1 mg/kg) inhibits MDA-MB-231 tumor growth in vivo, causes a significant dose-dependent decrease in tumor volume and either completely blocked or caused a marked decrease in the incidence and number of skeletal as well as soft tissue metastases.

物理化学性质&存储条件

分子量	712.66
分子式	C25H35F3N8O11S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	L-Aspartamide, 1-acetyl-L-prolyl-L-histidyl-L-seryl-L-cysteinyl-, mono(trifluoroacetate) (salt)

参考文献

1. Cianfrocca ME, et al. Br J Cancer. 2006 Jun 5;94(11):1621-6.

2. Livant DL, et al. Cancer Res. 2000 Jan 15;60(2):309-20.

3. Khalili P, et al. Mol Cancer Ther. 2006 Sep;5(9):2271-80.

ATN-161 TFA salt (Ac-PHSCN-NH2, ATN161)

生物&药学活性

物理化学性质&存储条件

参考文献

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ATN-161 TFA salt (Ac-PHSCN-NH2, ATN161)

生物&药学活性

物理化学性质&存储条件

参考文献

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