AJM347 | α4β7 integrin antagonist | Probechem Biochemicals

Chemical Structure : AJM347

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AJM347 (AJM-347)

货号: PC-27662Not For Human Use, Lab Use Only.

AJM347 is a potent, selective and orally active α4β7 integrin antagonist, inhibits the binding of immune cells expressing α4β7 integrin to gastrointestinal submucosa, while not interacting with cells expressing α4β1 integrin.

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生物&药学活性

AJM347 is a potent, selective and orally active α4β7 integrin antagonist, inhibits the binding of immune cells expressing α4β7 integrin to gastrointestinal submucosa, while not interacting with cells expressing α4β1 integrin.

物理化学性质&存储条件

分子量	840.86
分子式	C41H38F2N8O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	isopropyl (S)-2-(2,5-difluoro-4-((4-(2-(tetrahydro-2H-pyran-4-yl)pyrimidin-5-yl)phenyl)sulfonamido)benzamido)-3-(6-(1-methyl-2,4-dioxo-1,4-dihydropyrido[3,4-d]pyrimidin-3(2H)-yl)pyridin-3-yl)propanoate

参考文献

1. Koyama T, et al. J Clin Pharmacol. 2026 Aug;66(8):e70260.

AJM347 (AJM-347)

生物&药学活性

物理化学性质&存储条件

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AJM347 (AJM-347)

生物&药学活性

物理化学性质&存储条件

参考文献

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