SC-68448 |CAS:188804-07-1 Probechem Biochemicals

Chemical Structure : SC-68448

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SC-68448 (SC68448)

货号: PC-35693Not For Human Use, Lab Use Only.

SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.

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生物&药学活性

SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.
SC-68448 inhibits alpha(v)beta3-mediated endothelial cell proliferation in a dose-dependent manner but did not inhibit tumor cell proliferation in cell-based assays; inhibits angiogenesis in vivo in a basic fibroblast growth factor-induced rat corneal neovascularization model.

物理化学性质&存储条件

分子量	452.292
分子式	C19H19Cl2N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenepropanoic acid, beta-[[2-[[3-[(aminoiminomethyl)amino]benzoyl]amino]acetyl]amino]-3,5-dichloro-

参考文献

1. Carron CP, et al. Cancer Res. 1998 May 1;58(9):1930-5.

SC-68448 (SC68448)

生物&药学活性

物理化学性质&存储条件

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SC-68448 (SC68448)

生物&药学活性

物理化学性质&存储条件

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