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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-SC-68448
SC-68448

Chemical Structure : SC-68448

CAS No.: 188804-07-1

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SC-68448 (SC68448)

货号: PC-35693Not For Human Use, Lab Use Only.

SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3.
    SC-68448 inhibits alpha(v)beta3-mediated endothelial cell proliferation in a dose-dependent manner but did not inhibit tumor cell proliferation in cell-based assays; inhibits angiogenesis in vivo in a basic fibroblast growth factor-induced rat corneal neovascularization model.

    物理化学性质&存储条件

    分子量 452.292
    分子式 C19H19Cl2N5O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Benzenepropanoic acid, beta-[[2-[[3-[(aminoiminomethyl)amino]benzoyl]amino]acetyl]amino]-3,5-dichloro-

    参考文献

    1. Carron CP, et al. Cancer Res. 1998 May 1;58(9):1930-5.

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