Bexotegrast (PLN-74809) | αvβ6/αvβ1 integrin inhibitor

Chemical Structure : Bexotegrast

CAS No.: 2376257-44-0

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货号: PC-73406Not For Human Use, Lab Use Only.

Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively.

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生物&药学活性

Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively.

Bexotegrast (PLN-74809) inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively.

Bexotegrast (PLN-74809) has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung.

分子量	492.624
分子式	C27H36N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-((2-methoxyethyl)(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)butyl)amino)-2-(quinazolin-4-ylamino)butanoic acid

1. Anindya Roy, et al. Nat Commun. 2023 Sep 13;14(1):5660.