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首页-小分子抑制剂&激动剂-Cytoskeleton/Cell Adhesion Molecules-Integrin-AXT107
AXT107

Chemical Structure : AXT107

CAS No.: 2417491-82-6

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AXT107 (Gersizangitide, AXT-107)

货号: PC-72429Not For Human Use, Lab Use Only.

AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation.

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10 mg ￥1580 In stock
25 mg ￥2780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation.
AXT107 inhibits VEGF-, HGF-, and PDGF-BB–stimulated phosphorylation of VEGFR2, c-Met, and PDGFRb receptors.
AXT107 also reduced total VEGFR2 levels by increasing internalization, ubiquitination, and degradation.
AXT107 suppressed subretinal neovascularization (NV) in two mouse models predictive of effects in neovascular age-related macular degeneration (NVAMD) and inhibited retinal NV in a model predictive of effects in ischemic retinopathies.
A combination of AXT107 and the current treatment aflibercept suppressed subretinal NV better than either agent alone.
AXT107 significantly reduced VEGF-induced vascular leakage by 86% at 1 month and 70% at 2 months in rabbit eyes, demonstrating the longer effectiveness than Aflibercept.

物理化学性质&存储条件

分子量 2355.69
分子式 C111H167N29O28
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 Month
Shipping
Solubility

10 mM in H2O
Chemical Name/SMILES

L-Phenylalaninamide, L-leucyl-L-arginyl-L-arginyl-L-phenylalanyl-L-seryl-L-threonyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-aspartyl-L-isoleucyl-L-asparaginyl-L-α-aspartyl-L-valyl-L-isoleucyl-L-asparaginyl-

参考文献

1. Raquel Lima E Silva, et al. Sci Transl Med. 2017 Jan 18;9(373):eaai8030.

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