| Cat. No. |
Product Name |
Information |
| PC-21023 |
TIM-3 inhibitor A-41
TIM-3 inhibitor
|
TIM-3 inhibitor A-41 (TIM-3-IN-2) is small-molecule inhibitor of T-cell immunoglobulin and mucin domain 3 (TIM-3; HAVCR2) with SPR Kd value of 0.61 uM. |
| PC-20828 |
LAG-3 inhibitor SA-15-P
LAG-3 inhibitor
|
LAG-3 inhibitor SA-15-P is a small molecule dual inhibitor of LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 of 4.21 and 6.52 uM, respectively. |
| PC-38590 |
M351-0056
VISTA agonist
|
M351-0056 (M351-056) is a small molecule VISTA agonist with high affinity KD of 12.6 uM, inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, regulates type I interferon (IFN-I) and non-canonical NF-κB pathways. |
| PC-38588 |
Compound 6809-0223
VISTA inhibitor
|
Compound 6809-0223 is a small-molecule antagonist targeting the immune checkpoint VISTA, shows good binding affinity for murine VISTA (Kd=647 nM, VISTA-ECD). |
| PC-38587 |
L557-0155
VSIG-8/VISTA inhibitor
|
L557-0155 is a small molecule inhibitor of VSIG-8, prevents VSIG-8 binding to VISTA, promotes cytokine production and cell proliferation in PBMCs and suppresses melanoma growth. |
| PC-38146 |
VISTA inhibitor III
VISTA inhibitor
|
VISTA inhibitor III is a small-molecule ligand for immune checkpoint VISTA with IC50 of 480 nM in FRET assay. |
| PC-38145 |
NSC622608
VISTA inhibitor
|
NSC622608 (NSC 622608) is the first small-molecule ligand for immune checkpoint VISTA with IC50 of 4.8 uM in FRET assay. |
| PC-35927 |
RRx-001
CD47-SIRPα inhibitor
|
RRx-001 (RRx001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α. |
| PC-62015 |
DRI-C21045
CD40-CD40L inhibitor
|
DRI-C21045 is a novel small-molecule inhibitor of CD40-CD40L protein-protein interaction with IC50 of 0.17 uM in cell-based assays. |
| PC-27783 |
5-OE-RU
MR1 ligand, MAIT cell antigen
|
5-OE-RU is a natural product formed during bacterial synthesis of vitamin B2, potently activates mucosal associated invariant T (MAIT) cells and has immunomodulatory, inflammatory, and anticancer properties, binds to histocompatibility complex (MHC)-related protein MR1. |
| PC-27782 |
5-OP-RU
MR1 ligand, MAIT cell antigen
|
5-OP-RU is a natural product formed during bacterial synthesis of vitamin B2, potently activates mucosal associated invariant T (MAIT) cells and has immunomodulatory, inflammatory, and anticancer properties, binds to histocompatibility complex (MHC)-related protein MR1. |
