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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Immune Checkpoints-RRx-001
RRx-001

Chemical Structure : RRx-001

CAS No.: 925206-65-1

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RRx-001 (RRx001, RRX 001)

货号: PC-35927Not For Human Use, Lab Use Only.

RRx-001 (RRx001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α.

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5 mg ￥980 In stock
10 mg ￥1380 In stock
25 mg ￥2180 In stock
50 mg ￥3480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RRx-001 (RRx001) is a novel NO and hypoxia mediated anticancer agent with with epigenetic and immunologic activity, RRx-001 is a dual small molecule checkpoint inhibitor by downregulating CD47 and SIRP-α.
RRX-001 targets CD133 + /CD44 + cancer stem cells from colon cancer cell-lines, HT-29, Caco-2, and HCT116, and inhibits Wnt pathway signalling with downregulation of c-Myc.
RRX-001 inhibits HCT 116 and decreases levels of the DNA methyltransferases DNMT1 and DNMT3a in a time and dose-dependent manner.
RRX-001 (RRX001) is a chemosensitizer in multiple tumor types and disease states including malaria, hemorrhagic shock and sickle cell anemia.

物理化学性质&存储条件

分子量 268.023
分子式 C5H6BrN3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one

参考文献

1. Reid T, et al. Lancet Oncol. 2015 Sep;16(9):1133-1142. doi: 10.1016/S1470-2045(15)00089-3.

2. Scicinski J, et al. Redox Biol. 2015 Aug;5:422. doi: 10.1016/j.redox.2015.09.035.

3. Kim MM, et al. Transl Oncol. 2016 Apr;9(2):108-113.

4. Oronsky B, et al. Invest New Drugs. 2016 Jun;34(3):371-7.

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