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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Immune Checkpoints-NSC622608
NSC622608

Chemical Structure : NSC622608

CAS No.: 2593254-90-9

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NSC622608 (NSC 622608)

货号: PC-38145Not For Human Use, Lab Use Only.

NSC622608 (NSC 622608) is the first small-molecule ligand for immune checkpoint VISTA with IC50 of 4.8 uM in FRET assay.

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10 mg ￥1380 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg ￥5580 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NSC622608 (NSC 622608) is the first small-molecule ligand for immune checkpoint VISTA with IC50 of 4.8 uM in FRET assay.
NSC622608 disrupts VISTA-VSIG-3 interaction with IC50 of 9.7 uM in ELISA assays.
SPR screening confirmed binding of NSC622608 to VISTA ECD with an estimated KD of 6.2 uM.

物理化学性质&存储条件

分子量 322.239
分子式 C9H12BrN3OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-3-((furan-2-ylmethyl)imino)-N,N-dimethyl-3H-1,2,4-dithiazol-5-amine hydrobromide

参考文献

1. Moustafa T Gabr, et al. J Am Chem Soc. 2020 Sep 23;142(38):16194-16198.

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