| Cat. No. |
Product Name |
Information |
| PC-28523 |
Zecontimod
TCR inhibitor
|
Zecontimod (TCR-IN-1) is a potent selective T cell receptor (TCR) inhibitor, blocks cytokine (IL-2, TNFα, IFNγ, IL-17A) release, shows immunomodulatory activity. |
| PC-28452 |
CD28 inhibitor CA-23
CD28 antagonist
|
CD28 inhibitor CA-23 is a potent, specific small molecule inhibitor of CD28, binds directly to CD28 with MST KD of 0.732 uM, inhibits CD28-B7 engagement and CD28-dependent T cell activation. |
| PC-28380 |
MG-T-19
TIM-3 inhibitor
|
MG-T-19 is a potent, small-molecule T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3, HAVCR2) inhibitor with MST KD of 0.26 uM. |
| PC-28379 |
MG-C-30
CD27 agonist
|
MG-C-30 is a small molecule CD27 agonist with EC50 of 0.84 uM in 4-IBB and CD27 reporter cell assays, augments 4-IBB and CD27 signaling in vitro, potentiates the secretion of TNF-α and IFN-γ in PBMCs, activate natural killer cells, delays tumor growth in EG7-OVA tumor-bearing mice. |
| PC-28378 |
MG-V-53
VISTA inhibitor
|
MG-V-53 is a potent, high-affinity small-molecule VISTA inhibitor with SPR KD of 106 nM, mimics the interaction of VISTA mAb, has IC50 of 121 nM in FRET assays. |
| PC-28170 |
ICB-7
LILRB4/ILT3 binder, ILT3-SCG2 inhibitor
|
ICB-7 is a high affinity, direct Leukocyte immunoglobulin-like receptor B4 (LILRB4/ILT3) binder with MST Kd of 156 nM, binds D2 domain of ILT3, disrupts the ILT3-SCG2 (Secretogranin II) interaction and inhibits downstream SHP1, SHP2, and STAT3 signaling. |
| PC-28169 |
ORS-22
LILRB4/ILT3 ligand
|
ORS-22 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 9.2 nM, binds LILRB4 extracellular domain. |
| PC-28168 |
ORS-14
LILRB4/ILT3 ligand
|
ORS-14 is a high affinity small molecule direct ligand of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3) with MST KD of 85.2 nM, binds LILRB4 extracellular domain. |
| PC-28144 |
LILRB4 inhibitor compound 4
LILRB4 inhibitor
|
LILRB4 inhibitor compound 4 is a high affinity, brain-penetrant leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3/CD85k) inhibitor, inhibits LILRB4-ApoE interaction with IC50 of 40.6 nM in ELISA assays. |
| PC-27678 |
CD155 inhibitor B7
CD155 inhibitor
|
CD155 inhibitor B7 is a blood-brain barrier-permeable small molecule CD155 (Poliovirus receptor, PVR) inhibitor, shows potent anti-proliferative activity GBM cell line LN229 with IC50 of 3.43 uM. |
| PC-27495 |
IL4I1-IN-1
IL4I1 inhibitor
|
IL4I1-IN-1 is a potent, selective interleukin 4-induced protein 1 (IL4I1) inhibitor with EC50 of 2 nM, inhibits IL4I1-mediated oxidative deamination of phenylalanine, reducing the production of phenylpyruvate, H2O2 and NH3. |
| PC-27380 |
GL-4512
LILRB4 inhibitor
|
GL-4512 a potent, small molecule direct modulator of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3/CD85k) with SPR KD of 39.2 nM for binding to immobilized LILRB4 protein, inhibits LILRB4-SCG2 interaction with IC50 of 37 nM in TR-FRET assays, inhibits LILRB4-mediated immunosup pressive signaling pathways relevant to tumor immune evasion. |
