CD28 inhibitor CA-23 | CD28 antagonist | Probechem Biochemicals

Chemical Structure : CD28 inhibitor CA-23

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CD28 inhibitor CA-23 (CA23)

货号: PC-28452Not For Human Use, Lab Use Only.

CD28 inhibitor CA-23 is a potent, specific small molecule inhibitor of CD28, binds directly to CD28 with MST KD of 0.732 uM, inhibits CD28-B7 engagement and CD28-dependent T cell activation.

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生物&药学活性

CD28 inhibitor CA-23 is a potent, specific small molecule inhibitor of CD28, binds directly to CD28 with MST KD of 0.732 uM, inhibits CD28-B7 engagement and CD28-dependent T cell activation.
CA-23 exhibits no detectable binding to CD80, CD86, or CTLA-4 even at 100 uM.
CA-23 inhibits CD28-CD80 and CD28-CD86 interactions with IC50 values of 35.3 nM and 23.9 nM, respectively.
CA-23 inhibits B7 binding to cell-surface CD28, dose-dependently suppresses CD28-mediated T cell activation with an IC50 of 424.4 nM.
CA-23 blocks CD28-driven T cell activation in human blood without independent agonism.
CA-23 (1-10 mg/kg) ameliorates T cell transfer-induced colitis by suppressing pathogenic Th1 and Th17 responses in vivo.
CA-23 suppresses pathogenic cytokine and Th1/Th17 responses in PBMCs from patients with active IBD.

物理化学性质&存储条件

分子量	393.86
分子式	C17H12ClNO4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-N-((1,3-dihydroisobenzofuran-5-yl)sulfonyl)benzo[b]thiophene-2-carboxamide

参考文献

1. Cho S, et al. bioRxiv [Preprint]. 2026 Aug 15:2026.08.10.744081.

CD28 inhibitor CA-23 (CA23)

生物&药学活性

物理化学性质&存储条件

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CD28 inhibitor CA-23 (CA23)

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