CD155 inhibitor B7

Chemical Structure : CD155 inhibitor B7

加入收藏

货号: PC-27678Not For Human Use, Lab Use Only.

CD155 inhibitor B7 is a blood-brain barrier-permeable small molecule CD155 (Poliovirus receptor, PVR) inhibitor, shows potent anti-proliferative activity GBM cell line LN229 with IC50 of 3.43 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CD155 inhibitor B7 is a blood-brain barrier-permeable small molecule CD155 (Poliovirus receptor, PVR) inhibitor, shows potent anti-proliferative activity GBM cell line LN229 with IC50 of 3.43 uM.
B7 shows an IC50 ranging from 3.43 to 14.60 uM for four human GBM cell lines (U87-MG, U251-MG, LN229, and U118-MG) using MTS assay.
(10 and 20 mg/kg) significantly inhibited tumor growth in U-87 xenograft model.
B7 significantly inhibited the proliferation of GSCs with IC50 of 6.1 uM, inhibiting proliferation, inducing apoptosis, and blocking sphere formation.
B7 enhances the cytotoxicity of NK-92 cells by targeting CD155-mediated immune checkpoint interactions.
demonstrates significant anti-GBM effects with dual-mode anti-GSC mechanisms that directly suppressed GSCs while concurrently activated NK cell-mediated immunity via the CD155/TIGIT/CD226 immune checkpoint axis within the tumor immune microenvironment (TIME).
B7 weakens the binding affinity of CD155-TIGIT and strengthens the binding of CD155-CD226 in protein interaction assays.

物理化学性质&存储条件

分子量	310.48
分子式	C22H30O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-methylbenzyl)-4-(2,4,4-trimethylpentan-2-yl)phenol

参考文献

1. Yong-Jian Wang, et al. Adv Sci (Weinh). 2025 Aug;12(32):e06688.