M351-0056 (M351-056)

Chemical Structure : M351-0056

CAS No.: 1189495-81-5

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货号: PC-38590Not For Human Use, Lab Use Only.

M351-0056 (M351-056) is a small molecule VISTA agonist with high affinity KD of 12.6 uM, inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, regulates type I interferon (IFN-I) and non-canonical NF-κB pathways.

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3480	In stock
25 mg	￥5480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

M351-0056 (M351-056) is a small molecule VISTA agonist with high affinity KD of 12.6 uM, inhibits the activation of the JAK2-STAT2 pathway, reduces the phosphorylation levels of JAK2 and STAT2, regulates type I interferon (IFN-I) and non-canonical NF-κB pathways.

M351-0056 decreases the levels of cytokines (IFN-γ, IL-17A, TNF-α, IL-2 and IL-1β).

M351-0056 improves imiquimod-induced psoriasis-like skin inflammation, reduces autoantibody levels, kidney damage and immune cell expansion in mice susceptible to chronic graft-versus-host disease and lupus, and delays the progression of systemic lupus erythematosus.

物理化学性质&存储条件

分子量	447.355
分子式	C15H12BrFN2O2S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-bromo-2-fluorophenyl)-2-methyl-5-(2-methylthiazol-4-yl)thiophene-3-sulfonamide

参考文献

1. Patent CN108743590, Small molecule compound having affinity with VISTA and use thereof. 2. Hu X, et al. Br J Pharmacol. 2021 Mar;178(6):1445-1458.