LAG-3 inhibitor SA-15-P | LAG-3 inhibitor | Probechem Biochemicals

Chemical Structure : LAG-3 inhibitor SA-15-P

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LAG-3 inhibitor SA-15-P (SA-15-P)

货号: PC-20828Not For Human Use, Lab Use Only.

LAG-3 inhibitor SA-15-P is a small molecule dual inhibitor of LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 of 4.21 and 6.52 uM, respectively.

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生物&药学活性

LAG-3 inhibitor SA-15-P is a small molecule dual inhibitor of LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 of 4.21 and 6.52 uM, respectively.
SA-15-P blocks LAG-3-mediated interactions in coculture cellular assays.
SA-15-P inhibits the interaction between both proteins expressed on cell surfaces with IC50 of 6.95 uM.
SA-15-P is a cell-active dual inhibitor of the interactions of LAG-3 with major histocompatibility complex (MHC) class II and fibrinogen-like protein 1 (FGL1).

物理化学性质&存储条件

分子量	428.49
分子式	C26H24N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC=CO1)NC2=CC=C(OCC(C3=C(C)N(CC4=CC=CC=C4)C(C)=C3)=O)C=C2

参考文献

1. Somaya A Abdel-Rahman, et al. ACS Med Chem Lett. 2023 Apr 11;14(5):629-635.

LAG-3 inhibitor SA-15-P (SA-15-P)

生物&药学活性

物理化学性质&存储条件

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LAG-3 inhibitor SA-15-P (SA-15-P)

生物&药学活性

物理化学性质&存储条件

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